Concordant DNA Methylation in Synchronous Colorectal Carcinomas
نویسندگان
چکیده
منابع مشابه
Concordant DNA methylation in synchronous colorectal carcinomas.
Epigenetic changes have been proposed as mediators of the field defect in colorectal carcinogenesis, which has implications for risk assessment and cancer prevention. As a test of this hypothesis, we evaluated the methylation status of eight genes (MINT1, 2, 31, MLH1, p16, p14, MGMT, and ESR1), as well as BRAF and KRAS mutations, in 57 multiple colorectal neoplasias (M-CRN) and compared these t...
متن کاملCancer Prevention Research Concordant DNA Methylation in Synchronous Colorectal Carcinomas
Epigenetic changes have been proposed as mediators of the field defect in colorectal carcinogenesis, which has implications for risk assessment and cancer prevention. As a test of this hypothesis, we evaluated the methylation status of eight genes (MINT1, 2, 31, MLH1, p16, p14, MGMT, and ESR1), as well as BRAF and KRAS mutations, in 57 multiple colorectal neoplasias (M-CRN) and compared these t...
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Microarray analysis of promoter hypermethylation provides insight into the role and extent of DNA methylation in the development of colorectal cancer (CRC) and may be co-monitored with the appearance of driver mutations. Colonic biopsy samples were obtained endoscopically from 10 normal, 23 adenoma (17 low-grade (LGD) and 6 high-grade dysplasia (HGD)), and 8 ulcerative colitis (UC) patients (4 ...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2009
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-09-0054